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Antibodies

BMP-8

Product Sizes
100 ug
£674.12
101-M239-100UG
About this Product
SKU:
101-M239
Additional Names:
BMP8B; OP2; BMP8
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
1M37
Clonality:
Monoclonal
Extra Details:
BMP8, also known as osteogenic protein 2 (OP2), was first isolated from a hippocampal library in a screen to identify relatives of BMP7/ OP1. BMPs are a family of structurally and functionally related proteins and represent a subfamily of the transforming growth factor B Beta (TGFB Beta) superfamily. BMPs are involved in a wide range of processes including embryogenesis, tissue morphogenesis, cell differentiation and migration, and tumorigenesis. Cellular responses to BMPs are mediated by heterooligomeric complexes of type I and type II serine/threonine kinase receptors . BMP8a and BMP8b, produced from separate genes, share 98% aa sequence identity in human but only 74% in mouse within the mature regions. Human BMP8a is synthesized as a 402 aa precursor protein that is cleaved between Arg263 and Ala264 to release the Cterminal mature protein. Mature human BMP 8a shares 90% and 68% aa sequence identity with mouse mature BMP8a and 8b, respectively. BMP8a is expressed during pregnancy in the deciduum and trophoblast cells, by inner root sheath cells of developing hair follicles, and by the epididymis and spermatids). In the mouse it cooperates with BMP7 in the maintenance of spermatogenesis but is not required for the initiation of spermatogenesis (7, 8). BMP8b, in contrast, is required for both the initiation and maintenance of spermatogenesis. BMP8a is induced during osteoblast differentiation at the onset of mineralization and during the osteogenic phase of bone repair in osteoblasts and osteocytes (1012). BMP8a/b is also highly expressed in osteosarcomas.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
Recombinant human BMP-8
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody