Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

BMP-3

Product Sizes
100 ug
£674.12
101-M234-100UG
About this Product
SKU:
101-M234
Additional Names:
BMP3; BMP-3A
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
6J24
Clonality:
Monoclonal
Extra Details:
BMP3, also known as osteogenin, the most abundant BMP in adult bone, is one of at least 15 structurally and functionally related BMPs, which are members of the TGFB Beta superfamily (13). BMPs were originally identified as protein regulators of cartilage and bone formation. They have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs also regulate the growth, differentiation, chemotaxis, and apoptosis of various cell types. Similar to most other TGFB Betafamily proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human and rat BMP3 are 98% identical. BMP3 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. Biologically active BMP3 is a disulfidelinked homodimer of the carboxyterminal 110 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond (4). The role of BMP3 in bone is contradictory since, unlike osteogenin purified from bone, recombinant BMP3 has not shown osteogenic function (5). Several studies indicate that BMP3 is an inhibitor of osteogenic BMPs. BMP3 dorsalizes Xenopus embryos, the opposite effect of BMP2 or 4, which cause ventralization. BMP3 inhibits alkaline phosphatase production and induction of osteoblastic target genes in undifferentiated mesenchymal and osteogenic cell lines that have been treated with BMP2. BMP3 also induces the expression of TGFB Beta/ activin responsive genes, but not BMPresponsive genes.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human BMP-3
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody