ADAM-9
Product Sizes
100 ug
£674.12
101-M209-100UG
About this Product
- SKU:
- 101-M209
- Additional Names:
- ADAM9; MCMP; MDC9; CORD9; Mltng
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 8A15
- Clonality:
- Monoclonal
- Extra Details:
- ADAM9, also known as MDC9 or meltrin G Gamma, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Metturn expected for reprolysins, a disintegrin-like domain, a cysteinerich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factor-A Alpha (TNFA Alpha), the p75 TNF receptor, the B Betaamyloid protein precursor, and the c-kit ligand 1, implying that it may participate in shedding of these membrane proteins. In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor. In addition, it also cleaves oxidized insulin B Betachain and fibronectin. Besides its catalytic activity, ADAM9 functions as an adhesion molecule through binding of its disintegrin domain to integrins such as A AlphavB Beta5 and A Alpha6B Beta1. The cytoplasmic domain of ADAM9 interacts with Src homology 3 (SH3)containing proteins and protein kinase C, and may mediate different signaling pathways. ADAM9 is widely expressed in tissues.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human ADAM-9 (extracellular domain)
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody