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Antibodies

ADAM-9

Product Sizes
100 ug
£674.12
101-M209-100UG
About this Product
SKU:
101-M209
Additional Names:
ADAM9; MCMP; MDC9; CORD9; Mltng
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
8A15
Clonality:
Monoclonal
Extra Details:
ADAM9, also known as MDC9 or meltrin G Gamma, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Metturn expected for reprolysins, a disintegrin-like domain, a cysteinerich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factor-A Alpha (TNFA Alpha), the p75 TNF receptor, the B Betaamyloid protein precursor, and the c-kit ligand 1, implying that it may participate in shedding of these membrane proteins. In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor. In addition, it also cleaves oxidized insulin B Betachain and fibronectin. Besides its catalytic activity, ADAM9 functions as an adhesion molecule through binding of its disintegrin domain to integrins such as A AlphavB Beta5 and A Alpha6B Beta1. The cytoplasmic domain of ADAM9 interacts with Src homology 3 (SH3)containing proteins and protein kinase C, and may mediate different signaling pathways. ADAM9 is widely expressed in tissues.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human ADAM-9 (extracellular domain)
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody