CCL-3 (MIP1 alpha)
Product Sizes
100 ug
£674.12
101-M187-100UG
About this Product
- SKU:
- 101-M187
- Additional Names:
- CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
- Buffer:
- PBS
- translate.label.attr.clone:
- 7D34
- Clonality:
- Monoclonal
- Extra Details:
- The macrophage inflammatory proteins 1A Alpha and 1B Beta were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1A Alpha refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1A Alpha. Mature MIP1A Alpha and MIP1B Beta in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the B Beta (CC) subfamily of chemokines. Both MIP1A Alpha and MIP1B Beta are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1A Alpha and MIP1B Beta preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1A Alpha has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1A Alpha has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1A Alpha has been identified as CCR1 and CCR5.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human CCL-3
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody