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Antibodies

ALK4 (Activin R1B)

Product Sizes
100 ug
£674.12
101-M175-100UG
About this Product
SKU:
101-M175
Additional Names:
ACVR1B; ALK4; SKR2; ACTRIB; ACVRLK4
Application:
Immunohistochemistry, Western Blot
Buffer:
PBS
translate.label.attr.clone:
11A7
Clonality:
Monoclonal
Extra Details:
Activin RIB, also known as ALK4, is a glycosylated 58 kDa type I receptor in the superfamily of TGFB Beta serine/threonine kinase receptors. Activin RIB associates with Activin RIIB to form a receptor complex for activin and inhibin molecules. These ligands bind to Activin RIIB which then associates with and phosphorylates the cytoplasmic domain of Activin RIB to initiate signal transduction. Mature human Activin RIB consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain. Within the ECD, human Activin RIB shares 93% and 95% aa sequence identity with mouse and rat Activin RIB, respectively. It shares 25-35% aa sequence identity with other human type I receptors Activin RIA, Activin RIC, BMPRIA, BMPRIB, and TGFB Beta R1. Alternately spliced isoforms of Activin RIB have deletions in the cytoplasmic domain and function as dominant negative inhibitors of activin signaling. Activin receptor signaling is modulated by the direct interaction of Activin RIB with cripto or inhibin binding protein. Activin RIB is excluded from the signaling complex if Activin RIIB first binds inhibin and betaglycan. Activin RIB functions in a wide variety of growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation and apoptosis, and tumorigenesis.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human ALK4 extracellular doamin
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody