ALK2 (Activin R1A)
Product Sizes
100 ug
£674.12
101-M173-100UG
About this Product
- SKU:
- 101-M173
- Additional Names:
- ACVR1; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 9J17
- Clonality:
- Monoclonal
- Extra Details:
- Activin RIA, also known as ALK2, TSK7L, SKR1, TSRI, and ACTRI, is a glycosylated 65 kDa type I receptor in the TGFB Beta serine/threonine kinase receptor family. Binding of TGFB Beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins. Activin RIA functions in a wide variety of growth and differentiation processes including gastrulation, skeletal system development, and cardiac morphogenesis. Mature human Activin RIA consists of a 103 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 363 aa cytoplasmic region that includes a Gly/Serrich GS box and the kinase domain. Within the ECD, human Activin RIA shares 99% and 94% aa sequence identity with mouse and rat Activin RIA, respectively. It shares 20% 26% aa sequence identity with other human type I receptors Activin RIB, BMPRIA, BMPRIB, and TGFB Beta RI. BMP signaling through Activin RIA is enhanced by the direct interaction between Activin RIA and RGMB/ DRAGON, a BMP coreceptor that also associates with other type I and type II receptors. Activin RIA can additionally phosphorylate the coreceptor Endoglin and is required for the inhibitory effect of Endoglin on prostate cancer cell motility.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human ALK2 extracellular domain
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody