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Antibodies

TNF-alpha

Product Sizes
500 ug
£370.59
101-M17-500UG
About this Product
SKU:
101-M17
Additional Names:
TNF; DIF; TNFA; TNFSF2; TNF-alpha
Application:
Block/Inhibit/Neutralise, ELISA, IHC-Paraffin, Western Blot
Buffer:
PBS
Clonality:
Monoclonal
Extra Details:
Tumor necrosis factor alpha (TNF-A Alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-A Alpha is produced by a wide variety of immune and epithelial cell types. Human TNF-A Alpha consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-A Alpha shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-A Alpha. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.
Formulation:
lyophilized from PBS
Host:
Mouse
Immunogen:
Recombinant human TNF-alpha
Isotype:
IgG1, kappa
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody