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Antibodies

MMP-3

Product Sizes
100 ug
£674.12
101-M110-100UG
About this Product
SKU:
101-M110
Additional Names:
MMP3; SL-1; STMY; STR1; CHDS6; MMP-3; STMY1
Application:
IHC-Paraffin, Western Blot
Buffer:
PBS
translate.label.attr.clone:
3E44
Clonality:
Monoclonal
Extra Details:
Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP3 (stromelysin1), can degrade a broad range of substrates including collagen A Alpha chains, aggrecan, laminin, fibronectin, elastin, casein, A Alpha1 antitrypsin, myelin basic protein, IL1B Beta, IGFBP3, pro MMP1, pro MMP7, pro MMP8, pro MMP9 and pro MMP13. MMP3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP3 in roles other than direct tissue remodelling, for instance, enzyme cascades and cytokine regulation. MMP3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells and macrophages. Structurally, MMP3 may be divided into several distinct domains; a prodomain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexinlike) domain.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human MMP-3
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody