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Antibodies

alpha FAP

Product Sizes
100 ug
£674.12
101-M103-100UG
About this Product
SKU:
101-M103
Additional Names:
Fibroblast activation protein alpha, Prolyl endopeptidase FAP, Integral membrane serine protease
Application:
ELISA, Flow Cytometry
Buffer:
PBS
translate.label.attr.clone:
16F50
Clonality:
Monoclonal
Extra Details:
FAP is a 760 amino acid long type II transmembrane glycoprotein. It contains a very short cytoplasmic N terminal part (6 amino acids), a transmembrane region (amino acids 7-26), and a large extracellular part with an alpha/beta-hydrolase domain and an eight-bladed beta-propeller domain.[9][10] A soluble form of FAP, which lacks the intracellular and transmembrane part, is present in blood plasma.[11] FAP is a non-classical serine protease, which belongs to the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9.[12] FAP is most closely related to DPPIV (approximately 50% of their amino acids are identical). The active site of FAP is localized in the extracellular part of the protein and contains a catalytic triad composed of Ser624 Asp702 His734 in humans and mice.[10] FAP is catalytically active as a 170kD homodimer and has a dipeptidase and an endopeptidase activity.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
Recombinant Human alphaFAP
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody