alpha FAP
Product Sizes
100 ug
£674.12
101-M103-100UG
About this Product
- SKU:
- 101-M103
- Additional Names:
- Fibroblast activation protein alpha, Prolyl endopeptidase FAP, Integral membrane serine protease
- Application:
- ELISA, Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- 16F50
- Clonality:
- Monoclonal
- Extra Details:
- FAP is a 760 amino acid long type II transmembrane glycoprotein. It contains a very short cytoplasmic N terminal part (6 amino acids), a transmembrane region (amino acids 7-26), and a large extracellular part with an alpha/beta-hydrolase domain and an eight-bladed beta-propeller domain.[9][10] A soluble form of FAP, which lacks the intracellular and transmembrane part, is present in blood plasma.[11] FAP is a non-classical serine protease, which belongs to the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9.[12] FAP is most closely related to DPPIV (approximately 50% of their amino acids are identical). The active site of FAP is localized in the extracellular part of the protein and contains a catalytic triad composed of Ser624 Asp702 His734 in humans and mice.[10] FAP is catalytically active as a 170kD homodimer and has a dipeptidase and an endopeptidase activity.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Recombinant Human alphaFAP
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody