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Proteins and Peptides

SDF-1 gamma (CXCL12)

Product Sizes
2 ug
£178.82
100-449-2UG
10 ug
£307.06
100-449-10UG
About this Product
SKU:
100-449
Additional Names:
Stromal-Cell Derived Factor-1, PBSF
Extra Details:
The SDF-1 proteins are stromal-derived CXC chemokines that signal primarily through the CXCR4 receptor. SDF-1 proteins exert chemotactic activity over a broad range of immune system cell types and may also be involved in other processes including metastasis of certain cancers, inflammation, and angiogenesis. Additionally, SDF-1 can suppress HIV entry into cells expressing the CXCR4 receptor. Five isomers of SDF-1 have been found with SDF-1A Alpha being the predominant form, expressing in a wide range of cell types. The SDF-1G Gamma isoform is distinctive in that it contains a highly basic C-terminal region, which presumably is the reason for its high binding affinity to gylcosaminoglycans (GAG) and heparin sulfate (HS). Consequently, most of SDF-1G Gamma exists in a cell- and membrane-bound form, which confers greater stability compared to other isoforms via increased resistance to proteolytic degradation. SDF-1G Gamma binds with reduced affinity to the CXCR4 receptor when compared to the A Alpha and B Beta isoforms, but because of its increased stability can, over time, exert equal or greater activity when compared to other SDF-1 isoforms. SDF-1G Gamma expression has been found primarily in the heart (human and mouse) and in the brain and central nervous system (rat). Recombinant Human SDF-1G Gamma (CXCL12) is an 11.6 kDa protein containing 98 amino acid residues.
Formulation:
lyophilized
Molecular Weight:
11.6 kDa
Purity:
≥98%
Reactivities:
Human
Sequence:
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKGR REEKVGKKEK IGKKKRQKKR KAAQKRKN
Shipping Conditions:
Ambient
Storage Conditions:
Room Temperature
Supplier:
ReliaTech
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins