SDF-1 gamma (CXCL12)
Product Sizes
2 ug
£178.82
100-449-2UG
10 ug
£307.06
100-449-10UG
About this Product
- SKU:
- 100-449
- Additional Names:
- Stromal-Cell Derived Factor-1, PBSF
- Extra Details:
- The SDF-1 proteins are stromal-derived CXC chemokines that signal primarily through the CXCR4 receptor. SDF-1 proteins exert chemotactic activity over a broad range of immune system cell types and may also be involved in other processes including metastasis of certain cancers, inflammation, and angiogenesis. Additionally, SDF-1 can suppress HIV entry into cells expressing the CXCR4 receptor. Five isomers of SDF-1 have been found with SDF-1A Alpha being the predominant form, expressing in a wide range of cell types. The SDF-1G Gamma isoform is distinctive in that it contains a highly basic C-terminal region, which presumably is the reason for its high binding affinity to gylcosaminoglycans (GAG) and heparin sulfate (HS). Consequently, most of SDF-1G Gamma exists in a cell- and membrane-bound form, which confers greater stability compared to other isoforms via increased resistance to proteolytic degradation. SDF-1G Gamma binds with reduced affinity to the CXCR4 receptor when compared to the A Alpha and B Beta isoforms, but because of its increased stability can, over time, exert equal or greater activity when compared to other SDF-1 isoforms. SDF-1G Gamma expression has been found primarily in the heart (human and mouse) and in the brain and central nervous system (rat). Recombinant Human SDF-1G Gamma (CXCL12) is an 11.6 kDa protein containing 98 amino acid residues.
- Formulation:
- lyophilized
- Molecular Weight:
- 11.6 kDa
- Purity:
- ≥98%
- Reactivities:
- Human
- Sequence:
- KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKGR REEKVGKKEK IGKKKRQKKR KAAQKRKN
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins