Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Proteins and Peptides

IL-37 (IL-1F7)

Product Sizes
5 ug
£178.82
100-161-5UG
25 ug
£307.06
100-161-25UG
About this Product
SKU:
100-161
Additional Names:
Interleukin-37, IL-1F7, IL-1Z Zeta (zeta), IL-1H4
translate.label.attr.clone:
(#34U21)
Extra Details:
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of proinflammatory cytokines including IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37.
Formulation:
lyophilized
Host:
Rat
Molecular Weight:
19.4 kDa
Purity:
> 95% by SDS-PAGE & HPLC analyses
Reactivities:
Human
Sequence:
MVHTSPKVKN LNPKKFSIHD QDHKVLVLDS GNLIAVPDKN YIRPEIFFAL ASSLSSASAE KGSPILLGVS KGEFCLYCDK DKGQSHPSLQ LKKEKLMKLA AQKESARRPF IFYRAQVGSW NMLESAAHPG WFICTSCNCN EPVGVTDKFE NRKHIEFSFQ PVCKAEMSPS EVSD
Shipping Conditions:
Ambient
Storage Conditions:
Room Temperature
Supplier:
ReliaTech
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins