FAS Ligand, soluble
Product Sizes
2 ug
£178.82
100-157-2UG
10 ug
£307.06
100-157-10UG
About this Product
- SKU:
- 100-157
- Additional Names:
- FASLG; FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1 S1697
- translate.label.attr.clone:
- Rabbit IgG
- Extra Details:
- Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells. Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells. FasL has the ability to kill T cells and activated B cells which leads to down-regulation of the immune response. The mechanism of Fas induced apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. Both human and murine sFasL are fully active on human and murine cells. Recombinant human soluble Fas Ligand is a 17.9 kDa protein (175 amino acid residues) comprising the TNF homologous region of FasL plus an eight His-Tag.
- Formulation:
- lyophilized
- Molecular Weight:
- 17.9 kDa
- Purity:
- >95%
- Reactivities:
- Human, Mouse
- Sequence:
- HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Room Temperature
- Supplier:
- ReliaTech
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins