PCNA Monoclonal Antibody
Product Sizes
100 ul
£362.00
RDSA55182-100UL
About this Product
- SKU:
- RDSA55182
- Additional Names:
- Cyclin;DNA polymerase delta auxiliary protein;HGCN8729;MGC8367;Mutagen-sensitive 209 protein;OTTHUMP00000030189;OTTHUMP00000030190;PCNA;Pcna/cyclin;PCNA_HUMAN;PCNAR;Polymerase delta accessory protein;Proliferating cell nuclear antigen.
- Application:
- Immunocytochemistry, Immunoprecipitation, Western Blot
- Clonality:
- Monoclonal
- Extra Details:
- Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase,but not apurinic-apyrimidinic (AP) endonuclease,APEX2 activities.Has to be loaded onto DNA in order to be able to stimulate APEX2.Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair:Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases,while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.|This is a PCNA Monoclonal Antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Mouse
- Immunogen:
- Purified recombinant human PCNA protein fragments expressed in E.coli.
- Isotype:
- IgG2b
- Molecular Weight:
- 36kda
- Reactivities:
- Hamster, Human, Mouse, Non-human Primate, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Reddot
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:pcna-monoclonal-antibody-48069.html
