MMP-2 Polyclonal Antibody
Product Sizes
50 ul
£218.00
RD90749A-50UL
100 ul
£359.00
RD90749A-100UL
About this Product
- SKU:
- RD90749A
- Additional Names:
- 72 kDa Type IV Collagenase,72 kDa Gelatinase,Gelatinase A,Matrix Metalloproteinase-2,MMP-2,TBE-1,MMP2,CLG4A,CLG4,MMP-II,MONA,TBE-1
- Application:
- Western Blot
- Buffer:
- PBS with 0.02% sodium azide,50% glycerol pH 7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN),Her2/neu,growth factors,cytokines,and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor,usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity,MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems,including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.|This is a MMP-2 Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human MMP-2 Protein expressed by E.coli
- Isotype:
- IgG
- Molecular Weight:
- 39 kDa
- Purification:
- Affinity Purified
- Reactivities:
- Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Reddot
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:mmp-2-polyclonal-antibody-33091.html
