PYCARD Polyclonal Antibody
Product Sizes
60 ul
£319.00
RD90271A-60UL
120 ul
£479.00
RD90271A-120UL
200 ul
£761.00
RD90271A-200UL
About this Product
- SKU:
- RD90271A
- Additional Names:
- A, Asc, TMS-, TNS1, masc, CARD5, TMS-1, 9130417A21Rik
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions.|This is a PYCARD Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Rabbit
- Immunogen:
- Recombinant fusion protein of mouse PYCARD
- Isotype:
- IgG
- Molecular Weight:
- 45-70KDa
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Reddot
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:pycard-polyclonal-antibody-29259.html
