PRKDC Polyclonal Antibody
Product Sizes
20 ul
£148.00
RD71068A-20UL
60 ul
£242.00
RD71068A-60UL
120 ul
£372.00
RD71068A-120UL
200 ul
£585.00
RD71068A-200UL
About this Product
- SKU:
- RD71068A
- Additional Names:
- DNA dependent protein kinase catalytic subunit,DNA PK catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PK catalytic subunit,DNA-PKcs,DNAPK,DNAPK catalytic subunit,DNPK 1,DNPK1,Hyper radiosensitivity of murine scid mutation,complementin
- Application:
- ELISA, IHC-Paraffin, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D.|This is a PRKDC Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the C-terminal region of human DNA-PKCS
- Isotype:
- IgG
- Molecular Weight:
- 450 kDa
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Reddot
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:prkdc-polyclonal-antibody-8373.html
