APC Anti-Mouse Foxp3 Antibody
Product Sizes
50 tests
£284.00
RD30461F-50TESTS
100 tests
£404.00
RD30461F-100TESTS
2 x 100 tests
£581.00
RD30461F-2X100TESTS
About this Product
- SKU:
- RD30461F
- Additional Names:
- Forkhead box protein P3,IPEX,JM2,Foxp3
- Application:
- Flow Cytometry, Immunocytochemistry
- Buffer:
- PBS
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 D Delta2) lacking exon 2.|This is a APC Anti-Mouse Foxp3 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Mouse
- Isotype:
- IgG1, kappa
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Reddot
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:apc-anti-mouse-foxp3-antibody-7612.html
