DUT Polyclonal Antibody
Product Sizes
20 ul
£148.00
RD252896A-20UL
60 ul
£242.00
RD252896A-60UL
120 ul
£372.00
RD252896A-120UL
200 ul
£585.00
RD252896A-200UL
About this Product
- SKU:
- RD252896A
- Additional Names:
- Deoxyuridine 5' triphosphate nucleotidohydrolase,nuclear isoform,Deoxyuridine 5'-triphosphate nucleotidohydrolase,mitochondrial,Deoxyuridine triphosphatase,dut,DUT,dUTP nucleotidohydrolase,dUTP pyrophosphatase,dUTPase,FLJ20622
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 1.08 mg/ml
- Extra Details:
- This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.|This is a DUT Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human DUT
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Reddot
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:dut-polyclonal-antibody-4564.html
