PPM1D Polyclonal Antibody
Product Sizes
20 ul
£148.00
RD252172A-20UL
60 ul
£242.00
RD252172A-60UL
120 ul
£372.00
RD252172A-120UL
200 ul
£585.00
RD252172A-200UL
About this Product
- SKU:
- RD252172A
- Additional Names:
- EC 3.1.3.16,p53 induced protein phosphatase 1,p53-induced protein phosphatase 1,PP2C delta,PP2C-delta,PP2CD,Ppm1d,PPM1D,Protein phosphatase 1D,protein phosphatase 1D magnesium-dependent delta isoform ,Protein phosphatase 2C delta isoform,Protein phosphata
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.|This is a PPM1D Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human PPM1D
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Reddot
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ppm1d-polyclonal-antibody-4052.html
