CGAS Polyclonal Antibody
Product Sizes
20 ul
£148.00
RD217843A-20UL
60 ul
£242.00
RD217843A-60UL
120 ul
£372.00
RD217843A-120UL
200 ul
£585.00
RD217843A-200UL
About this Product
- SKU:
- RD217843A
- Additional Names:
- C6orf150,cGAMP synthase,cGAS,CGAS,cGMP Synthase,Chromosome 6 open reading frame 150,Cyclic GMP-AMP synthase,h-cGAS,Hypothetical protein LOC115004,Mab 21 domain containing 1,Mab-21 domain-containing protein 1,MB21D1,MGC131892,MGC142166,MGC142168,OTTHUMP000
- Application:
- ELISA, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 0.78 mg/ml
- Extra Details:
- Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).|This is a CGAS Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human MB21D1
- Isotype:
- IgG
- Molecular Weight:
- Refer to figures
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Reddot
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:cgas-polyclonal-antibody-1537.html
