anti-Keratin K15, guinea pig polyclonal antibody
Product Sizes
100 ul
£334.00
GP-CK15-100UL
About this Product
- SKU:
- GP-CK15
- Additional Names:
- Keratin, type I cytoskeletal 15, Cytokeratin-15, CK-15, Keratin-15, K15, KRT15, KRTB
- Application:
- Immunohistochemistry, Western Blot
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Extra Details:
- Mr 50 kDa (pI 4.9) intermediate filament polypeptide, keratin K15 (formerly also designated cytokeratin 15), detected by immunofluorescence microscopy in basal cells of stratified epithelia (including epidermis, tongue, esophagus, exocervix) and complex stratified epithelia (e.g. broncheal epithelium), in luminal epithelia of mammary, salivary and sweat gland. In the hair follicle, staining was restricted to the outermost cell layer of the outer root sheath; within the hair follicle several cell layers of the hair follicle bulb were positive with antiserum gp 15.1. In human fetal tissues keratin K15 was localized in basal cells of epidermis, lung, trachea, tracheal glands and esophagus. In fetal hair anlagen, all cells were positive with antiserum gp 15.1, suggesting that keratin K15 is preferentially expressed in epithelial stem cells. Completely unreactive were cells of liver, colon, kidney, urinary bladder, pancreas and lung alveolus. In tumors, gp15.1 is reactive with squamous skin and lung carcinomas and with a significant subgroup of invasive ductal breast carcinomas, especially tumors with higher grade malignancy. Reactivity on cultured cell lines: HaCat, A-431; negative on PLC.
- Formulation:
- Contains 0.09% sodium azide and 0.5% BSA
- Host:
- Guinea Pig
- Immunogen:
- C-terminal tail region (including parts of the rod domain) of human recombinant keratin K15
- Purification:
- Stabilized antiserum
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:GP-CK15
