anti-MFG-E8/ Lactadherin, MFG-06, mouse monoclonal antibody
Product Sizes
100 ug
£432.00
691710-100UG
About this Product
- SKU:
- 691710
- Additional Names:
- Lactadherin, Breast epithelial antigen BA46, HMFG, MFGM, Milk fat globule-EGF factor 8, MFG-E8, SED1 [Cleaved into: Lactadherin short form; Medin], MFGE8
- Application:
- FACS, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MFG-06
- Clonality:
- Monoclonal
- Concentration:
- 100 ug/ml
- Extra Details:
- MFG-06 reacts with a glycoprotein of 40-45 kDa, known as Milk fat globule-EGF factor 8 protein (MFG-E8), lactadherin, p47 or milk fat globule 1 antigen. It is present on normal epithelial cells in various organs and considered a differentiation marker in carcinomas. It contains one EGF-like domain and 2 F5/8 type C domains. Functioning as a specific ligand for Integrin beta 5 and Integrin beta 3, MFG-E8 is thought to be involved in gamete interactions and cell attachment, possibly playing a role in fertilization and apoptosis. Additionally, MFG-E8 binds to rotavirus and inhibits its replication, thereby protecting the cell from viral infection. Overexpression of MFG-E8 is associated with breast cancer, suggesting that MFG-E8 may be related to tumorigenesis or progression. Among testicular carcinomas, seminomas are negative. Positive control: normal breast or breast carcinoma.
- Formulation:
- PBS with 0.02% sodium azide
- Host:
- Mouse
- Immunogen:
- Milk fat globule membrane preparation derived from human breast cancer cell line PMC42
- Isotype:
- IgG1, kappa
- Purification:
- Affinity Purified
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:691710
