anti-Estrogen-Receptor, ER-70, mouse monoclonal antibody
Product Sizes
100 ug
£432.00
691684-100UG
About this Product
- SKU:
- 691684
- Additional Names:
- Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1
- Application:
- Immunohistochemistry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- ER-70
- Clonality:
- Monoclonal
- Concentration:
- 100 ug/ml
- Extra Details:
- ER-70 is specific to ER alpha (67 kDa) and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates are increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. Structurally ER consists of 6 functional domains (domain A-F). Functional mapping of the estrogen receptor has determined a transcriptional promoting activity in the A/B domain. The hormone-binding domain (E domain) is located towards the carboxy terminal, whereas the DNA-binding domain (C-domain) is found in the central portion of the molecule. It has been speculated that the presence in breast cancer cells of truncated forms of estrogen receptor lacking the hormone-binding domain might promote the uncontrolled growth of the tumor. The ER-70 epitope is located in the transcriptional promoting (A/B) domain of ER). Positive control: Human uterus, ER positive breast cancer, MCF-7 cells.
- Formulation:
- PBS with 0.02% sodium azide
- Host:
- Mouse
- Immunogen:
- Recombinant human estrogen receptor alpha protein (aa2-85)
- Isotype:
- IgG1, kappa
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:691684
