anti-C. difficile ToxinA, EBS-I-100, mouse monoclonal antibody
Product Sizes
100 ug
£432.00
691642-100UG
About this Product
- SKU:
- 691642
- Application:
- ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- EBS-I-100
- Clonality:
- Monoclonal
- Concentration:
- 100 ug/ml
- Extra Details:
- EBS-I-100 reacts with C. difficile Toxin A, but not with V. cholerae subunit a, V. cholerae toxin, Pseudomonas aeruginosa exotoxin A, H-LT and P-LT. C. difficile is a major nosocomial pathogen that causes antibiotic-associated colitis and mediates inflammatory diarrhea by releasing two large protein enterotoxins (toxin A and toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. C. difficile toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. C. difficile toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation. Positive control: Clostridium difficile extract or infected cells or tissue.
- Formulation:
- PBS with 0.02% sodium azide
- Host:
- Mouse
- Immunogen:
- C. difficile toxin A
- Isotype:
- IgG3, kappa
- Purification:
- Affinity Purified
- Reactivities:
- Bacteria
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:691642
