Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

anti-CD33 / SIGLEC3, 33-20, mouse monoclonal antibody

Product Sizes
100 ug
£432.00
691576-100UG
About this Product
SKU:
691576
Additional Names:
Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67, CD antigen CD33, CD33, SIGLEC3
Application:
FACS, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
CE/IVD:
RUO
translate.label.attr.clone:
33-20
Clonality:
Monoclonal
Concentration:
100 ug/ml
Extra Details:
CD33 is a 67 kDa glycoprotein of the sialic acid-binding immunoglobulin-like lectin (SIGLEC) family, displaying the immune-receptor tyrosine-based inhibitory motif (ITIM), able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic linage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. Positive control: human dendritic and mast cells. Human lymph node and tonsil.
Formulation:
PBS with 0.02% sodium azide
Host:
Mouse
Immunogen:
Stimulated human AML cells
Isotype:
IgG1, kappa
Purification:
Affinity Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Please refer to datasheet
Supplier:
Progen
Type:
Antibody: Monoclonal Antibody
  • Manufacturer's Data Sheet:691576