1;2;3;4-Tetrahydro Staurosporin
Product Sizes
1 mg
£ POA
HY-W740378-1MG
About this Product
- SKU:
- HY-W740378
- Additional Names:
- AFN-941
- CAS Number:
- 220038-19-7
- Extra Details:
- 1;2;3;4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).
- Molecular Weight:
- 470.56
- References:
- [1]Song, et al. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4):e2590,(2017).
- Research Area:
- Others
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
