(R)-(+)-Verapamil-d6 (hydrochloride)
Product Sizes
10 mg
£ POA
HY-W702292-10MG
1 mg
£ POA
HY-W702292-1MG
About this Product
- SKU:
- HY-W702292
- Application:
- Antibody Microarray
- CAS Number:
- 1795786-09-2
- Extra Details:
- (R)-(+)-Verapamil-d6 (hydrochloride) is deuterium labeled (R)-Verapamil (hydrochloride). (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport; resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2][3].
- Molecular Weight:
- 497.10
- References:
- [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39(4):787-92.|[3]Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
