1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
Product Sizes
5 mg
£ POA
HY-W583868-5MG
100 mg
£ POA
HY-W583868-100MG
25 mg
£ POA
HY-W583868-25MG
10 mg
£ POA
HY-W583868-10MG
50 mg
£ POA
HY-W583868-50MG
About this Product
- SKU:
- HY-W583868
- Additional Names:
- 1;2-POPE; 16:0-18:1 PE
- CAS Number:
- 26662-94-2
- Extra Details:
- 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1;2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines[1][2].
- Molecular Weight:
- 718.00
- Purity:
- 99.46
- References:
- [1]Álvarez-Benedicto E, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomater Sci. 2022 Jan 18;10(2):549-559.|[2]Guo L, et al. A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines. Anal Biochem. 2010 Oct 15;405(2):236-45.
- Research Area:
- Others
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Metabolic Enzyme/Protease
