(+)-Norfenfluramine
Product Sizes
100 mg
£ POA
HY-W131725-100MG
25 mg
£ POA
HY-W131725-25MG
50 mg
£ POA
HY-W131725-50MG
10mM/1mL
£ POA
HY-W131725-10MM
About this Product
- SKU:
- HY-W131725
- Additional Names:
- d-Norfenfluramine
- CAS Number:
- 19036-73-8
- Extra Details:
- (+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine; is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1].
- Molecular Weight:
- 203.20
- Purity:
- 99.92
- References:
- [1]Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. |[2]M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7. |[3]R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982 Mar;75(3):525-30.
- Research Area:
- Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Neuronal Signaling
