CL 5343
Product Sizes
100 mg
£ POA
HY-W074975-100MG
25 mg
£ POA
HY-W074975-25MG
5 mg
£ POA
HY-W074975-5MG
50 mg
£ POA
HY-W074975-50MG
10 mg
£ POA
HY-W074975-10MG
10mM/1mL
£ POA
HY-W074975-10MM
About this Product
- SKU:
- HY-W074975
- Additional Names:
- 5-Amino-1;3;4-thiadiazole-2-sulfonamide
- Application:
- Antibody Microarray
- CAS Number:
- 14949-00-9
- Extra Details:
- CL 5343 (5-Amino-1;3;4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I; II; IV; and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity; such as glaucoma; epilepsy; and cancer[1][2][3].
- Molecular Weight:
- 180.21
- Purity:
- 99.91
- References:
- [1]Aday B, et al. Synthesis of novel 5-amino-1,3,4-thiadiazole-2-sulfonamide containing acridine sulfonamide/carboxamide compounds and investigation of their inhibition effects on human carbonic anhydrase I, II, IV and VII. Bioorg Chem. 2018 Apr;77:101-105.|[2]Pesando JM, et al. Proton magnetic resonance studies of carbonic anhydrase. III. Binding of sulfonamides. Biochemistry. 1975;14(4):689-693.|[3]Pérez-Herrero E, et al. The reversed intra-and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers[J]. Acta Pharmaceutica Sinica B, 2021, 11(8): 2243-2264.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
