2′-Deoxy-2′-fluoroadenosine
Product Sizes
100 mg
£ POA
HY-W039442-100MG
About this Product
- SKU:
- HY-W039442
- Application:
- Antibody Microarray
- CAS Number:
- 64183-27-3
- Extra Details:
- 2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity; able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP[1][2][3].
- Molecular Weight:
- 269.24
- Purity:
- 99.71
- References:
- [1]A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.
- Research Area:
- Cancer; Infection
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; stored under nitrogen)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Cell Cycle/DNA Damage
