1;2;4-Trimethoxybenzene
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HY-W017087-1EACH
About this Product
- SKU:
- HY-W017087
- CAS Number:
- 135-77-3
- Extra Details:
- 1;2;4-Trimethoxybenzene is an orally active NLRP3 selective inhibitor. 1;2;4-Trimethoxybenzene can markedly suppress Nigericin (HY-127019) or ATP (HY-B2176)-induced NLRP3 inflammasome activation; thus decreasing caspase-1 activation and IL-1β secretion. 1;2;4-Trimethoxybenzene specifically inhibits the activation of NLRP3 inflammasome without affecting absent in melanoma 2 (AIM2) inflammasome activation. 1;2;4-Trimethoxybenzene inhibits oligomerization of the apoptosis-associated speck-like protein containing a CARD (ASC) and protein-protein interaction between NLRP3 and ASC; thus blocking NLRP3 inflammasome assembly. 1;2;4-Trimethoxybenzene can be used for the study of experimental autoimmune encephalomyelitis (EAE); multiple sclerosis; and type 2 diabetes[1][2][3].
- Molecular Weight:
- 168.19
- Purity:
- 98.43
- Research Area:
- Infection;Metabolic Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store at room temperature 3 years
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
