(E)-5-(2-Bromovinyl)pyrimidine-2;4(1H;3H)-dione
Product Sizes
10 mg
£ POA
HY-W014109-10MG
25 mg
£ POA
HY-W014109-25MG
50 mg
£ POA
HY-W014109-50MG
About this Product
- SKU:
- HY-W014109
- Additional Names:
- (E)-5-(2-Bromovinyl)uracil; BVU
- CAS Number:
- 69304-49-0
- Extra Details:
- (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg; increasing survival time.
- Molecular Weight:
- 217.02
- References:
- [1]De Clercq, et al. Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. J. Med. Chem. 29(2), 213-217 (1986).
- Research Area:
- Infection
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage
