(E/Z)-Locostatin
Product Sizes
50 mg
£ POA
HY-W013411-50MG
25 mg
£ POA
HY-W013411-25MG
5 mg
£ POA
HY-W013411-5MG
100 mg
£ POA
HY-W013411-100MG
10 mg
£ POA
HY-W013411-10MG
10mM/1mL
£ POA
HY-W013411-10MM
About this Product
- SKU:
- HY-W013411
- Additional Names:
- (E/Z)-UIC-1005
- CAS Number:
- 133812-16-5
- Extra Details:
- (E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
- Molecular Weight:
- 245.27
- Purity:
- 99.52
- References:
- [1]Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58.|[2]Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. |[3]Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- MAPK/ERK Pathway
