1;2;4-Trihydroxybenzene (Standard)
Product Sizes
100 mg
£ POA
HY-W010451R-100MG
25 mg
£ POA
HY-W010451R-25MG
10 mg
£ POA
HY-W010451R-10MG
50 mg
£ POA
HY-W010451R-50MG
About this Product
- SKU:
- HY-W010451R
- Additional Names:
- Hydroxyhydroquinone (Standard)
- CAS Number:
- 533-73-3
- Extra Details:
- 1;2;4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) is the analytical standard of 1;2;4-Trihydroxybenzene (HY-W010451). This product is intended for research and analytical applications. 1;2;4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1;2;4-Trihydroxybenzene selectively activates eIF2α phosphorylation; activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1;2;4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks; destroying organelles such as mitochondria and ER; and inducing cell death. 1;2;4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect; increase blood pressure; and relieve spasm[1][2][3][4].
- Molecular Weight:
- 126.11
- References:
- [1]Risa Kamae, et al. Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca<sup>2+</sup> concentration in rat thymic lymphocytes. Food Chem Toxicol. 2017 Apr;102:39-45.|[2]Jung DM, et al. 1,2,4-trihydroxybenzene induces stress granule formation and causes DNA damage in human keratinocytes. Toxicol In Vitro. 2023 Oct;92:105638.|[3]Park EJ, et al. 1,2,4-trihydroxybenzene induces non-apoptotic cell death via the structural damage of intracellular organelles. Toxicol Appl Pharmacol. 2024 Nov;492:117096.|[4]Inoue S. Effects of 1,3,5-trihydroxybenzene and 2,4,6-trihydroxy-1-propiophenone on the smooth muscle organs. Jpn J Pharmacol. 1969 Jun;19(2):224-33.
- Research Area:
- Cancer; Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel;Neuronal Signaling
