Amivantamab
Product Sizes
5 mg
£ POA
HY-P9977-5MG
10 mg
£ POA
HY-P9977-10MG
1 mg
£ POA
HY-P9977-1MG
25 mg
£ POA
HY-P9977-25MG
About this Product
- SKU:
- HY-P9977
- Additional Names:
- JNJ-61186372
- Application:
- Antibody Microarray
- CAS Number:
- 2171511-58-1
- Extra Details:
- Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding; promotes endocytosis and degradation of receptor-antibody complexes; and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells[1].
- Molecular Weight:
- (145.88 kDa)
- Purity:
- 99.90
- References:
- [1]Keunchil Park, et al. Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study. J Clin Oncol. 2021 Oct 20;39(30):3391-3402. |[2]Jiyeon Yun, et al. Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209.
- Research Area:
- Cancer;Inflammation/Immunology
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -80[o]C for 2 years
- Type:
- Antibodies
- Pathway:
- JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
