Cantuzumab mertansine
Product Sizes
1 mg
HY-P99492-1MG
5 mg
HY-P99492-5MG
25 mg
HY-P99492-25MG
10 mg
HY-P99492-10MG
About this Product
- SKU:
- HY-P99492
- Additional Names:
- SB-408075; huC242-DM1
- Application:
- Antibody Microarray
- CAS Number:
- 400010-39-1
- Extra Details:
- Cantuzumab mertansine (SB-408075; huC242-DM1); an ADC; is an immunoconjugate of the potent maytansine derivative (DM1 (HY-19792)) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].
- Molecular Weight:
- 150000 (average)
- Purity:
- 96.02
- References:
- [1]Paul R Helft, et al. A phase I study of cantuzumab mertansine administered as a single intravenous infusion once weekly in patients with advanced solid tumors. Clin Cancer Res. 2004 Jul 1;10(13):4363-8.|[2]Anthony W. Tolcher, et al. Cantuzumab Mertansine, a Maytansinoid Immunoconjugate Directed to the CanAg Antigen: A Phase I, Pharmacokinetic, and Biologic Correlative Study. J Clin Oncol. 2003 Jan 15;21(2):211-22.
- Research Area:
- Cancer
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -80[o]C; protect from light
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
- Pathway:
- Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
