KY-1044
Product Sizes
10 mg
£ POA
HY-P99431-10MG
1 mg
£ POA
HY-P99431-1MG
5 mg
£ POA
HY-P99431-5MG
About this Product
- SKU:
- HY-P99431
- Additional Names:
- Alomfilimab; SAR 445256
- CAS Number:
- 2489390-15-8
- Extra Details:
- KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels; such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response[1].
- Molecular Weight:
- (146.5 kDa)
- Purity:
- 99.51
- References:
- [1]Richard C.A. Sainson, et al. An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression. Cancer Immunol Res. 2020 Dec;8(12):1568-1582.
- Research Area:
- Cancer; Inflammation/Immunology
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -80[o]C for 2 years
- Type:
- Antibodies
- Pathway:
- Immunology/Inflammation
