Ligelizumab
Product Sizes
1 mg
HY-P99300-1MG
5 mg
HY-P99300-5MG
10 mg
HY-P99300-10MG
About this Product
- SKU:
- HY-P99300
- Additional Names:
- QGE 031; Anti-IGHE Recombinant Antibody
- CAS Number:
- 1322627-61-1
- Extra Details:
- Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI; while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil; while reducing the production of IgE by B cells; and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC). Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria; allergic asthma)[1][2].
- Molecular Weight:
- (146.32 kDa)
- Purity:
- 99.85
- References:
- [1]Gasser P, et al. The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nat Commun. 2020 Jan 8;11(1):165.|[2]Benito-Villalvilla C, et al. Ligelizumab impairs IgE-binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN-α production and FOXP3+ Treg generation. Allergy. 2023 Apr;78(4):1060-1072.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -80[o]C for 2 years
- Type:
- Antibodies
- Pathway:
- Others
