Anti-Mouse CD80 Antibody (TKMG48)
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HY-P992062-1EACH
About this Product
- SKU:
- HY-P992062
- Extra Details:
- Anti-Mouse CD80 Antibody (TKMG48) is an antibody that targets mouse CD80. By specifically binding to and disrupting the CD80:PD-L1 complex to release PD-L1; Anti-Mouse CD80 Antibody (TKMG48) functions as an indirect PD-1 agonist without blocking CD28 co-stimulation or CD80-CTLA4 binding. Anti-Mouse CD80 Antibody (TKMG48) inhibits T cell activation; reduces T cell effector functions and antigen-specific CD8+ T cell populations; and does not interfere with the differentiation; migration; antigen presentation or surface marker expression of dendritic cells. Anti-Mouse CD80 Antibody (TKMG48) significantly attenuates disease severity in mouse models of arthritis; spondyloarthritis; multiple sclerosis and Sjögren's syndrome; and its activity depends on the expression of PD-1 and PD-L1[1][2].
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Antibodies
