Anti-Mouse CXCR4 Antibody (Cx4Mab-1)
Product Sizes
Get quote
£ POA
HY-P991744-1EACH
About this Product
- SKU:
- HY-P991744
- Application:
- Antibody Microarray
- Extra Details:
- Anti-Mouse CXCR4 Antibody is a monoclonal antibody that specifically recognizes murine CXCR4 (C-X-C chemokine receptor 4); also known as fusin or CD184. CXCR4 is a seven-transmembrane G protein–coupled receptor whose principal endogenous ligand is CXCL12 (stromal cell–derived factor-1α; SDF-1α) and is widely expressed in hematopoietic cells; endothelial cells; neurons; as well as embryonic and adult stem cells. The CXCR4–CXCL12 signaling axis activates multiple downstream pathways; including ERK1/2; Ras; p38 MAPK; PLC/MAPK; and SAPK/JNK; thereby regulating cell survival; proliferation; migration; and stemness maintenance. Aberrant overexpression of CXCR4 is closely associated with poor prognosis and metastasis in various cancers; with CXCR4-positive tumor cells preferentially home to CXCL12-rich tissues such as the liver; bone marrow; lung; and lymph nodes. Accordingly; CXCR4 and its CXCL12-related antagonists emerge as attractive targets for experimental anticancer therapy. Anti-Mouse CXCR4 Antibody is generated using a cell-based immunization and screening strategy and exhibits high affinity for both endogenous and exogenous murine CXCR4. Anti-Mouse CXCR4 Antibody can be used for thestudy of chronic lymphocytic leukemia and multiple myeloma[1].
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Molecular Biology Reagents: Libraries
