KD014
Product Sizes
1 mg
£ POA
HY-P991316-1MG
5 mg
£ POA
HY-P991316-5MG
10 mg
£ POA
HY-P991316-10MG
25 mg
£ POA
HY-P991316-25MG
About this Product
- SKU:
- HY-P991316
- Additional Names:
- DX-2400; DX-2410
- Extra Details:
- KD014 (DX-2400) is a human monoclonal antibody that selectively targets MMP‑14. KD014 inhibits collagen degradation and regulates the polarization of macrophages toward an anti-inflammatory/anti-tumor phenotype. KD014 alleviates joint damage in rheumatoid arthritis and suppresses tumor growth and invasion. KD014 can be used in studies related to breast cancer and rheumatoid arthritis[1][2].
- Molecular Weight:
- (144.01 kDa)
- Purity:
- 96.98
- References:
- [1]Ager EI, et al. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. J Natl Cancer Inst. 2015 Feb 20;107(4):djv017.|[2]Devy L, et al. Antitumor efficacy of DX-2400, a potent and selective human antibody MMP-14 inhibitor discovered using phage display technology[J]. Cancer Research, 2007, 67(9_Supplement): 5618-5618.
- Research Area:
- Cancer;Inflammation/Immunology
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -80[o]C
- Type:
- Antibodies
