4-1BB/TNFRSF9; Human (Biotinylated; HEK293; His-Avi)
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HY-P78067-1EACH
About this Product
- SKU:
- HY-P78067
- Additional Names:
- 4-1BB/TNFRSF9 Protein; Human (Biotinylated; HEK293; His-Avi);Human;HEK293
- Extra Details:
- 4-1BB (CD137; TNFRSF9); a receptor of TNFSF9/4-1BBL; belongs to the tumor necrosis factor (TNF) receptor superfamily[1]. 4-1BB is helpful for T cell activation and development; and also induces peripheral mononuclear cell proliferation and migration to the tumor microenvironment[2]. 4-1BB is also involved in enhancing Nrf2 and NF-κB pathway mediated apoptosis of endothelial cells[3]. Human 4-1BB protein is a surface glycoprotein with a transmembrane domain (187-213 a.a.). 4-1BB/TNFRSF9 Protein; Human (Biotinylated; HEK293; His-Avi) is the extracellular part (L24-Q186) of 4-1BB protein; produced by HEK293 cells with C-terminal His- and Avi-tag.
- Molecular Weight:
- Approximately 30-45 kDa; based on SDS-PAGE under reducing conditions; due to the glycosylation.
- References:
- [1]Ye L, et al. CD137, an attractive candidate for the immunotherapy of lung cancer. Cancer Sci. 2020 May;111(5):1461-1467.|[2]Jiang P, et al. CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages. Theranostics. 2019 May 9;9(10):2950-2966.|[3]Geng T, et al. CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway. Mediators Inflamm. 2020 Jun 6;2020:4321912.|[4]Langstein J, et al. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochem Biophys Res Commun. 2000 Jun 24;273(1):117-22.|[5]Langstein J, et al. Identification of CD137 as a potent monocyte survival factor. J Leukoc Biol. 1999 Jun;65(6):829-33.|[6]Jiang D, et al. CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol. 2008 Sep 15;181(6):3923-32.
- Shipping Conditions:
- Dry Ice
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
