4-1BBL/TNFSF9; Rat (HEK293; Fc)
Product Sizes
Get quote
£ POA
HY-P76704-1EACH
About this Product
- SKU:
- HY-P76704
- Additional Names:
- 4-1BBL/TNFSF9 Protein; Rat (HEK293; Fc);Rat;HEK293
- Extra Details:
- 4-1BBL (4-1BB ligand) is a type II membrane protein of the TNF superfamily; is expressed on antigen-presenting cells. 4-1BB with 4-1BBL can induce T-cell expansion; cytokine induction; differentiation; and upregulation of anti-apoptotic genes as well as protect T cells from activation-induced cell death (AICD)[1]. 4-1BBL stimulates T cell proliferation and induces effective anti-tumor immune responses[3]. 4-1BBL is an immunostimulant molecule that interacts with the 4-1BB high-affinity receptor during the antigen presentation; providing costimulatory signals to both CD4+ and CD8+ T cells through the activation of NF-kB; c-Jun; and p38 downstream pathways; triggering pleiotropic effects on the immune system[4]. 4-1BBL/TNFSF9 Protein; Rat (HEK293; Fc) is a recombinant protein with a N-Terminal Fc label; It consists of 203 amino acids (P106-G308) and is produced in HEK293 cells.
- Molecular Weight:
- Approximately 61 kDa; based on SDS-PAGE under reducing conditions; due to the glycosylation.
- References:
- [1]Li Y, et al. Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep. 2018 Oct 23;25(4):909-920.e4.|[2]Bitra A, et al. Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding. J Biol Chem. 2019 Feb 8;294(6):1831-1845.|[3]Meseck M, et al. A functional recombinant human 4-1BB ligand for immune costimulatory therapy of cancer. J Immunother. 2011 Mar;34(2):175-82.|[4]Martinez-Perez AG, et al. 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer. Int J Mol Sci. 2021 Jun 9;22(12):6210.|[5]Salih HR, et al. Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. J Immunol. 2001 Oct 1;167(7):4059-66.
- Shipping Conditions:
- Dry Ice
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
