AITRL/TNFSF18; Human (HEK293; Fc)
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HY-P76110-1EACH
About this Product
- SKU:
- HY-P76110
- Additional Names:
- AITRL/TNFSF18 Protein; Human (HEK293; Fc);Human;HEK293
- Extra Details:
- AITRL; a type II transmembrane protein; is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR; GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor; inflammation; as well as autoimmune diseases[1]. Besides; AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1; ICAM-1)[2]. AITRL/TNFSF18 Protein; Human (HEK293; Fc) is a recombinant human AITRL (Q72-S199) with C-terminal mFc tag; which is expressed in HEK293.
- Molecular Weight:
- Approximately 46 kDa; based on SDS-PAGE under reducing conditions.
- References:
- [1]Tian J, et al. The Role of GITR/GITRL Interaction in Autoimmune Diseases. Front Immunol. 2020 Oct 9;11:588682.|[2]Lacal PM, et al. Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. J Pharmacol Exp Ther. 2013 Oct;347(1):164-72.|[3]Wang F, et al. Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun. 2021 Mar 2;12(1):1378.|[4]Placke T, et al. Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation. Clin Dev Immunol. 2010;2010:239083.|[5]Tian J, et al. Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome. J Immunol. 2019 Mar 15;202(6):1693-1703.
- Shipping Conditions:
- Dry Ice
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
