ALK-1; Cynomolgus (HEK293; Fc)
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HY-P75570-1EACH
About this Product
- SKU:
- HY-P75570
- Additional Names:
- ALK-1 Protein; Cynomolgus (HEK293; Fc);Cynomolgus;HEK293
- Extra Details:
- ALK-1; also known as ACVRL1; is a type I receptor for TGF-β superfamily with 2 ligands; BMP9 and BMP10. ALK-1 is predominantly expressed in endothelial cells and plays a critical role in regulating developmental and pathological angiogenesis[1][2]. ALK-1 Protein; Cynomolgus (HEK293; Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 118 amino acids (M1-Q118).
- Molecular Weight:
- Approximately 53 kDa;based on SDS-PAGE under reducing conditions.
- References:
- [1]S P Oh, et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31.|[2]Dianyuan Zhao, et al. ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection. J Clin Invest. 2022 Feb 1;132(3):e150489.|[3]Dianne Mitchell, et al. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol Cancer Ther. 2010 Feb;9(2):379-88.|[4]Kerstin Wöltje, et al. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS One. 2015 Mar 23;10(3):e0120547.
- Shipping Conditions:
- Dry Ice
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
