4-1BB/TNFRSF9; Mouse (isoform 2; HEK293; Fc)
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HY-P74335-1EACH
About this Product
- SKU:
- HY-P74335
- Additional Names:
- 4-1BB/TNFRSF9 Protein; Mouse (isoform 2; HEK293; Fc);Mouse;HEK293
- Extra Details:
- 4-1BB (CD137; TNFRSF9); a receptor of TNFSF9/4-1BBL; belongs to the tumor necrosis factor (TNF) receptor superfamily[1]. 4-1BB is helpful for T cell activation and development; and also induces peripheral mononuclear cell proliferation and migration to the tumor microenvironment[2]. 4-1BB is also involved in enhancing Nrf2 and NF-κB pathway mediated apoptosis of endothelial cells[3]. Mouse 4-1BB protein is a surface glycoprotein with a transmembrane domain (188-208 a.a.). 4-1BB/TNFRSF9 Protein; Mouse (isoform 2; HEK293; Fc) has 188 amino acids (V24-L211); produced by HEK293 cells with C-terminal rFc-tag.
- References:
- [1]Ye L, et al. CD137, an attractive candidate for the immunotherapy of lung cancer. Cancer Sci. 2020 May;111(5):1461-1467.|[2]Jiang P, et al. CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages. Theranostics. 2019 May 9;9(10):2950-2966.|[3]Geng T, et al. CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway. Mediators Inflamm. 2020 Jun 6;2020:4321912.|[4]Pauly S, et al. CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers. J Leukoc Biol. 2002 Jul;72(1):35-42.
- Shipping Conditions:
- Dry Ice
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
