Siglec-2/CD22; Mouse (HEK293; Fc)
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HY-P73646-1EACH
About this Product
- SKU:
- HY-P73646
- Additional Names:
- Siglec-2/CD22 Protein; Mouse (HEK293; Fc);Mouse;HEK293
- Extra Details:
- Siglec-2/CD22 Protein; Mouse (690a.a; HEK293; Fc) is a Siglec of ~140 kDa with seven Ig-like domains and is expressed in a B-cell lineage-specific fashion; starting at the pre-B cell stage. CD22 is associated with membrane-bound IgM on the surface of B cells. Siglec-2 (CD22) specifically recognizes 伪2.6 sialic acid-containing glycans. Siglec-2 negatively regulates B cell antigen receptor (BCR) signaling by recruitment and activation of SH2-containing phosphatase 1 (SHP-1); which counteracts the phospharylation-mediated activation of signaling molecules by dephosphorylation; and reduces Ca2+ signaling by regulating the activity of the Ca2+ pump PMCA[1][2]. Siglec-2/CD22 Protein; Mouse (HEK293; Fc) is the recombinant mouse-derived Siglec-2/CD22 protein; expressed by HEK293 ; with C-hFc labeled tag.
- Molecular Weight:
- Approximately 125 kDa;based on SDS-PAGE under reducing conditions.
- Shipping Conditions:
- Dry Ice
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
