Azurin p28 peptide (TFA)
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HY-P5910A-1EACH
About this Product
- SKU:
- HY-P5910A
- Application:
- Antibody Microarray
- Extra Details:
- Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces apoptosis or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2; FAK and Akt[1][2][3].
- Molecular Weight:
- 2914.18(free base)
- References:
- [1]Mehta RR, et al. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 2011 Sep;14(3):355-69.|[2]Jia L, et al. Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother Pharmacol. 2011 Aug;68(2):513-24.|[3]Yamada T, et al. A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol Cancer Ther. 2009 Oct;8(10):2947-58.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
