Azurin p28 peptide
Product Sizes
1 mg
£ POA
HY-P5910-1MG
10 mg
£ POA
HY-P5910-10MG
5 mg
£ POA
HY-P5910-5MG
About this Product
- SKU:
- HY-P5910
- Application:
- Antibody Microarray
- CAS Number:
- 897026-25-4
- Extra Details:
- Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2; FAK and Akt[1][2][3].
- Molecular Weight:
- 2914.18
- Purity:
- 99.40
- References:
- [1]Jia L, et al. Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother Pharmacol. 2011 Aug;68(2):513-24.|[2]Yamada T, et al. A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol Cancer Ther. 2009 Oct;8(10):2947-58.|[3]Mehta RR, et al. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 2011 Sep;14(3):355-69.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Pathway:
- Apoptosis
